PhD graduates
Theses
Dissertations currently in progress:
Design and chemical synthesis of proprotein convertase inhibitors
Izabela Małuch MSc, promoter: prof. Adam Prahl, PhD, DSc
Ongoing research focuses on the search for a compound that potently and selectively inhibits the activity of PACE4, an enzyme belonging to the proprotein convertase family. PACE4 plays a key role in prostate cancer development by directing the progression of tumor growth toward greater aggressiveness, and inhibition of this enzyme leads to a significant loss of tumorigenicity by human prostate cancer cells. Inhibitors of this enzyme are seen as an opportunity to block further progression of the disease.
Design and chemical synthesis of furin inhibitors
Monika Lewandowska MSc, promoter: prof. Adam Prahl, PhD, DSc
The purpose of this dissertation is to design, synthesize and determine the activity of potential inhibitors of furin, an enzyme in the precursor protein convertase family. This enzyme is involved in a number of fundamental physiological processes and is responsible for initiating viral infections and other disease states, so its inhibitors could serve to design potential therapeutic agents.
Studies using capillary electrophoresis
mgr Teresa Łepek MSc, promoter: prof. Adam Prahl, PhD, DSc
Dissertations completed:
2010
Małgorzata Śleszyńska, PhD: Design and chemical synthesis of bradykinin analogues containing conformationally limiting amino acid residues in the C-terminal fragment of the molecule, promoter prof. Adam Prahl, PhD, DSc
Anna Kwiatkowska, PhD: Design, synthesis and biological properties of peptides: pro-protein convertase inhibitors and neurohormone analogues, promoter prof. Bernard Lammek, PhD, DSc
2008
Dariusz Sobolewski, PhD: Effects of selected modifications of the N-terminal fragment of the arginine moiety of vasopressin and its analogues on pharmacological activity, promoter prof. Bernard Lammek, PhD, DSc
2007
Olga Labudda, PhD: Bradykinin analogues and their n-acylated derivatives modified at the c-terminal fragment of the molecule with conformational restriction residues, promoter prof. Bernard Lammek, PhD, DSc
2006
Wioleta Kowalczyk, PhD: Synthesis of neurohormone analogues containing a conformational restriction fragment in the molecule, promoter prof. Bernard Lammek, PhD, DSc
2005
Emilia Sikorska, PhD: Conformational studies of vasopressin and its analogues using nuclear magnetic resonance spectroscopy, promotor prof. dr hab. Bernard Lammek
2004
Rafał Ślusarz, PhD: Molecular dynamics simulation of G protein-coupled receptor blocking and activation, promoter prof. Bernard Lammek, PhD, DSc
2002
Beata Jastrzębska, PhD: Design and synthesis of neurotransmitter hormone analogues containing conformational restriction fragments, promoter prof. Bernard Lammek, PhD, DSc
2000
Elżbieta Kamysz, PhD: Effects of selected modifications of neurohormone molecules on their biological function, promoter prof. Bernard Lammek, PhD, DSc