Research topics

Research topics carried out in

Department of Bioinorganic Chemistry

Macroscopically, scientific research carried out in the Laboratory of Intermolecular Interactions, operating within the Department of Bioinorganic Chemistry is interdisciplinary in nature, constituting a borderline between the fields of chemistry, pharmacy and biotechnology. The issues raised in the microscopic description combine the fields of bioinorganic, structural, analytical and theoretical chemistry.  Experimental and theoretical studies are conducted to explain the molecular, crystalline and/or electronic structures, the nature of intermolecular interactions and to understand the spectroscopic, acid-base, redox and electrolytic properties of biologically active compounds (ligands) and their complexes with transition metal ions (III/ II).

Scientific work carried out in our group covers the following aspects:

• synthesis, analysis of structures and physicochemical properties of the following compounds using molecular spectroscopy: FT-IR, FT-Raman, electron UV-VIS, NMR, IR, roentgenography, potentiometry;
• design of new crystalline materials, including organic compounds that are bioligands and their coordination compounds of d-block metal ions (including cationic polymeric systems);
• characteristics of: heterocyclic bioligands such as: pyrazine derivatives, antibiotics and vitamins and their complexes with d-block metal ions; drugs and inorganic toxins; new non-platinum coordination compounds of ruthenium, osmium, iridium, copper, iron, nickel, cadmium, cobalt with potential use as chemotherapeutics and/or antibacterial/antifungal agents; new complexes used in analytics: cationic polymeric complexes that are new-generation acidity indicators; molecular dynamics, including theoretical studies of structures and vibrational spectra using computational methods of quantum chemistry;
• conformational equilibria and complex formation equilibria in aqueous solutions;
• acid-base equilibria of ligands and their complexes in aqueous and non-aqueous solutions;
• xperimental and theoretical studies of intermolecular interactions, including hydrogen bonds formed in small systems (pyrazine/vitamin/antibiotic derivatives used as ligands) and in larger biomolecules (side chains of amino acid residues of peptides and proteins);
• isolation of ligands with selected metals in the solid state;